Structure
IKK16, Inhibitor
IKK16
Purity
>98% (HPLC)
Synonyms
IKK16; IKK 16; inhibitor
Purity/Purification
>98% (HPLC)
Target
IkappaB kinase (IKK)
Receptor
IkappaB kinase (IKK)
Chemical Name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
SMILES
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
Molecular Formula
C28H31ClN6OS
CAS Number
1186195-62-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for IKK16, inhibitor
IKK16 is a potent, selective inhibitor of IkappaB kinase (IKK) with IC50 of 40, 70 and 200nM for IKKbeta, IKK complex and IKKalpha respectively; inhibits TNF-alpha-stimulated IkappaB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3uM respectively; inhibits LPS-induced TNF-alpha release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.
Product Categories/Family for IKK16, inhibitor
References
1. Waelchli R, et al. Bioorg Med Chem Lett. 2006 Jan 1; 16 (1):108-12.
2. Thein S, et al. Biochem Biophys Res Commun. 2014 Jul 18; 450 (1):550-4.
3. Sordi R, et al. Mol Med. 2015 Jun 18; 21:563-75.
4. Liu JC, et al. Cell Rep. 2018 Apr 3; 23 (1):112-126.
2. Thein S, et al. Biochem Biophys Res Commun. 2014 Jul 18; 450 (1):550-4.
3. Sordi R, et al. Mol Med. 2015 Jun 18; 21:563-75.
4. Liu JC, et al. Cell Rep. 2018 Apr 3; 23 (1):112-126.
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Product Notes
The IKK16 (Catalog #AAA3600632) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IKK16, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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