Structure
BAY 11-7085 Biochemical
BAY 11-7085
Purity
>98% (HPLC)
Synonyms
BAY 11-7085; BAY11-7085; BAY-11-7085; BAY 11-7083; BAY 11-7085 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=26mg/mL
Target
NF-kappaB
Receptor
IkappaBalphaphosphorylation
Chemical Name
2-Propenenitrile, 3-[[4-(1, 1-dimethylethyl)phenyl]sulfonyl]-, (2E)
SMILES
N#C/C=C/S(=O)(C1=CC=C(C(C)(C)C)C=C1)=O
Molecular Formula
C13H15NO2S
CAS Number
196309-76-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 11-7085 biochemical
An inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10uM); acts by selectively inhibiting TNFalpha-induced phosphorylation of IkappaB-alpha without affecting the constitutive IkappaB-alpha phosphorylation; prevents PMA-induced NF-kappaB nuclear translocation; reduces swelling in both the rat carrageenan paw edema assay and in a rat adjuvant arthritis model.
Product Categories/Family for BAY 11-7085 biochemical
References
1. Pierce JW, et al. J Biol Chem. 1997 Aug 22; 272 (34):21096-103.
2. Hu X, et al. Cancer Res. 2001 Aug 15; 61 (16):6290-6.
3. Vielma SA, et al. Circ Res. 2003 May 30; 92 (10):1130-7.
2. Hu X, et al. Cancer Res. 2001 Aug 15; 61 (16):6290-6.
3. Vielma SA, et al. Circ Res. 2003 May 30; 92 (10):1130-7.
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Product Notes
The BAY 11-7085 (Catalog #AAA3603081) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 11-7085, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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