Structure
Tofimilast, Inhibitor
Tofimilast
Purity
>98% (HPLC)
Synonyms
Tofimilast; CP-325366; inhibitor
Purity/Purification
>98% (HPLC)
Target
PDE
Receptor
PDE
Chemical Name
9-Cyclopentyl-7-ethyl-3-(thiophen-2-yl)-6, 9-dihydro-5H-pyrazolo(3, 4-c)-1, 2, 4-triazolo(4, 3-a)pyridine
SMILES
CCC1=NN(C2CCCC2)C3=C1CCN4C3=NN=C4C5=CC=CS5
Molecular Formula
C18H21N5S
CAS Number
185954-27-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Tofimilast, inhibitor
Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13nM for PDE4A, PDE4B, and PDE4D, respectively; shows weakly or no inhibition for PDE4C, and no activity for PDE1, PDE2, PDE3, PDE5, PDE6, and PDE7; increases cAMP levels in PGE1-stimulated U937 cells with an EC50 of 230nM, inhibits human monocyte PDE mediated cAMP catabolism with an IC50 of 67nM and LPS stimulated human monocyte TNFalpha release with an IC50 of 59nM; shows low oral bioavailability and no emesis-associated behaviors in the ferret emesis model. Asthma Discontinued
Product Categories/Family for Tofimilast, inhibitor
References
1. Duplantier AJ, et al. J Med Chem. 2007 Jan 25; 50 (2):344-9.
2. Giembycz MA. Br J Pharmacol. 2008 Oct; 155 (3):288-90.
2. Giembycz MA. Br J Pharmacol. 2008 Oct; 155 (3):288-90.
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Product Notes
The Tofimilast (Catalog #AAA3602872) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tofimilast, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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