Structure
HSD992, Inhibitor
HSD992
Purity
>98% (HPLC)
Synonyms
HSD992; HSD 992; HSD-992; inhibitor
Purity/Purification
>98% (HPLC)
Target
CDK
Receptor
CDK
Chemical Name
6-(8, 9, 10, 11-tetrahydro-3H-pyrrolo[3, 2-a]phenanthridin-7-yl)benzo[d]thiazol-2-amine
Molecular Formula
C22H18N4S
CAS Number
2222045-50-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HSD992, inhibitor
HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18nM, 57nM and 49nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively; only poorly inhibits the activities of CDKs 1, 4, 5, 6, 14, 16, 17, 18 and 19, and does not inhibit PLK isoforms; inhibits HLY-1 and NCI-H520 with IC50 values of 232nM and 307nM, respectively, The IC50 values against other cell lines (LC-2/Ad, K562, HeLa, NCI-H1703 and DMS114) ranged from 427nM to 723nM.
Product Categories/Family for HSD992, inhibitor
References
1. Opoku-Temeng C, et al. Chem Commun (Camb). 2018 Apr 9. doi: 10.1039/c8cc01154k.
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Product Notes
The HSD992 (Catalog #AAA3603544) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HSD992, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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