Goat NBEA/Neurobeachin Polyclonal Antibody | anti-NBEA antibody

Anti-NBEA/Neurobeachin Antibody (aa2934-2946)

Cat. Num. AAA2401017

• Gene Names: NBEA; BCL8B; LYST2
• Reactivity: Human; Predicted: Xenopus, Chicken, Zebrafish, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Hamster, Monkey
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: NBEA/Neurobeachin; Polyclonal Antibody; Anti-NBEA/Neurobeachin Antibody (aa2934-2946); Goat Polyclonal to Human NBEA/Neurobeachin; NBEA; LYST2; Neurobeachin; Protein BCL8B; BCL8B; KIAA1544; anti-NBEA antibody

• Host: Goat
• Reactivity: Human; Predicted: Xenopus, Chicken, Zebrafish, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Hamster, Monkey
• Clonality: Polyclonal
• Specificity: Human NBEA/Neurobeachin. This antibody is expected to recognise isoform 1 (NP_056493.3) and isoform 2 (NP_001191126.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 2946

• Applicable Applications for anti-NBEA antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 10 ug/ml; WB: 1-3 ug/ml
• Immunogen: Synthetic peptide C-DFNRWHYEHQNRY from the C-terminus of human NBEA/Neurobeachin (NP_056493.3; NP_001191126.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Elephant, Dog, Bovine, Bat, Horse, Rabbit, Opossum, Chicken, Platypus, Xenopus, Stickleback, Pufferfish, Zebrafish (100%).
• Conjugation: Unconjugated
• Epitope: aa2934-2946
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-NBEA/Neurobeachin antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Antibody (1 ug/ml) staining of 1) untransfected HEK293T cells 2) HEK293T cells transfected with mouse NBEA. Detected by chemiluminescence. Data kindly provided by Professor John Creemers, K. U. Leuven, Belgium.)

Related Product Information for anti-NBEA antibody

NBEA/Neurobeachin is a member of a large, diverse group of A-kinaseanchor proteins that target the activity of protein kinase A to specificsubcellular sites by binding to its type II regulatory subunits.Brain-specific expression and coat protein -like membrane recruitment of ahighly similar protein in mouse suggest an involvement in neuronalpost-Golgi membrane traffic. Mutations in this gene may be Associated with a form of autism.

NCBI and Uniprot Product Information

• NCBI GI #: 62422577
• NCBI GeneID: 26960
• NCBI Accession #: NP_056493.3
• NCBI GenBank Nucleotide #: NM_015678.4
• UniProt Accession #: Q8NFP9; Q5T320; Q9HCM8; Q9NSU1; Q9NW98; Q9Y6J1; B7Z2H9
• Molecular Weight: 84,001 Da
• NCBI Official Full Name: neurobeachin isoform 1
• NCBI Official Synonym Full Names: neurobeachin
• NCBI Official Symbol: NBEA
• NCBI Official Synonym Symbols: BCL8B; LYST2
• NCBI Protein Information: neurobeachin
• UniProt Protein Name: Neurobeachin
• Protein Family: Neurobeachin
• UniProt Gene Name: NBEA
• UniProt Synonym Gene Names: BCL8B; KIAA1544; LYST2

NCBI Description

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]

Uniprot Description

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins ().