Testing Data
(GW 791343 hydrochloride is a non-competitive human P2X(7) receptor inhibitor with pIC50 of about 7.1. GW 791343 hydrochloride exhibits negative allosteric effects at the human P2X(7) receptor but is a positive allosteric modulator of the rat P2X(7) receptor. GW 791343 hydrochloride competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor. GW 791343 hydrochloride increased responses to BzATP at the F95L mutant receptor, although the magnitude of this effect was not as marked as at the rat ECD, rat -human or domain 1 receptor. [1][2][3])
GW 791343, inhibitor
GW 791343 hydrochloride
Purity
>99%
Synonyms
GW 791343; GW 791343 hydrochloride; inhibitor
Purity/Purification
>99%
Solubility
Unknown
Formula
C20H24F2N4O.3HCl
CAS Number
309712-55-8
Preparation and Storage
Store at -20 degree C for 2 years.
Testing Data
(GW 791343 hydrochloride is a non-competitive human P2X(7) receptor inhibitor with pIC50 of about 7.1. GW 791343 hydrochloride exhibits negative allosteric effects at the human P2X(7) receptor but is a positive allosteric modulator of the rat P2X(7) receptor. GW 791343 hydrochloride competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor. GW 791343 hydrochloride increased responses to BzATP at the F95L mutant receptor, although the magnitude of this effect was not as marked as at the rat ECD, rat -human or domain 1 receptor. [1][2][3])
Testing Data
(GW 791343 hydrochloride is a non-competitive human P2X(7) receptor inhibitor with pIC50 of about 7.1. GW 791343 hydrochloride exhibits negative allosteric effects at the human P2X(7) receptor but is a positive allosteric modulator of the rat P2X(7) receptor. GW 791343 hydrochloride competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor. GW 791343 hydrochloride increased responses to BzATP at the F95L mutant receptor, although the magnitude of this effect was not as marked as at the rat ECD, rat -human or domain 1 receptor. [1][2][3])
Related Product Information for GW 791343, inhibitor
GW 791343 hydrochloride is a non-competitive human P2X(7) receptor inhibitor with pIC50 of about 7.1. GW 791343 hydrochloride exhibits negative allosteric effects at the human P2X(7) receptor but is a positive allosteric modulator of the rat P2X(7) receptor. GW 791343 hydrochloride competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X(7) receptor. GW 791343 hydrochloride increased responses to BzATP at the F95L mutant receptor, although the magnitude of this effect was not as marked as at the rat ECD, rat-human or domain 1 receptor. [1][2][3]
Product Categories/Family for GW 791343, inhibitor
References
[1] Michel AD et al. Br J Pharmacol. 2008 Feb; 153(4):737-50. [2] Michel AD et al. Br J Pharmacol. 2009 Apr; 156(8):1312-25. [3] Michel AD et al. Br J Pharmacol. 2008 Nov; 155(5):738-51. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Similar Products
Product Notes
The GW 791343 (Catalog #AAA8506527) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW 791343, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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