Testing Data
UK 383367, inhibitor
UK 383367
Purity
>99%
Synonyms
UK 383367; inhibitor
Purity/Purification
>99%
Solubility
Unknown
Formula
C15H24N4O4
CAS Number
348622-88-8
Preparation and Storage
Store at -20 degree C for 2 years.
Testing Data
Testing Data
Related Product Information for UK 383367, inhibitor
UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK 383367 inhibited deposition of insoluble collagen by 76 +/-2% at 10 muM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 mug/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK 383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 muM for them). [1][2][3]
Product Categories/Family for UK 383367, inhibitor
References
[1] Fish PV et al. J Med Chem. 2007 Jul 26; 50(15):3442-56. [2] Allan GA et al. Xenobiotica. 2006 May; 36(5):399-418. [3] Bailey S et al. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6562-7. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The UK 383367 (Catalog #AAA8506318) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UK 383367, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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