Chemical Structure
E7449, inhibitor
E7449
Purity
0.9713
Synonyms
E7449; UNII-9X5A2QIA7C; inhibitor
Purity/Purification
0.9713
Form/Format
Solid
Solubility
DMSO: 6.4mg/mL (20.17mM)
Need ultrasonic and warming
DMSO: 6.5mg/mL (20.5mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Need ultrasonic and warming
DMSO: 6.5mg/mL (20.5mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
O=C1NN=C(N2)C3=C(C=CC=C31)N=C2CN(C4)CC5=C4C=CC=C5
Formula
C18H15N5O
In vitro
E7449 moderately inhibits the growth of tumors at 100 mg/kg, and significantly ehhances the inhibition via 10, 30 and 100 mg/kg oral dosing in combination with temozolomide (TMZ) in the mouse melanoma B16-F10 isograft model[1].
CAS Number
1140964-99-3
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for E7449, inhibitor
E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2,with IC50s of 2.0, 1.0, ~50 and ~50 for PARP1,PARP2,TNKS1 and TNKS2,respectively, using 32P-NAD+ as substrate.
Product Categories/Family for E7449, inhibitor
References
McGonigle S, Chen Z, Wu J, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015;6(38):41307-41323. doi:10.18632/oncotarget.5846
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Product Notes
The E7449 (Catalog #AAA5764887) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "E7449, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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