Molecular Structure

Dimethylsphingosine, Inhibitor

Dimethylsphingosine

Purity

>97% (TLC); NMR (Conforms)

Synonyms

Dimethylsphingosine; Picropodophyllotoxin; (5R; 5aS; 8aR; 9R)-5; 8; 8a; 9-Tetrahydro¬-9-hydroxy-5-(3; 4; 5-trimethoxyphenyl)-furo[3'; 4':6; 7¬]naphtho[2; 3-d]-1; 3-dioxol-6(5aH)-one; (2S; 3R; E)-2-(dimethylamino)octadeca-4-ene-1; 3; diol; inhibitor

Ordering
Cat. Num. AAA515070 For Research Use Only!

Purity/Purification

>97% (TLC); NMR (Conforms)

Form/Format

White to off white waxy solid or viscous oil

CAS Number

119567-63-4

Molecular Formula

C₂₀H₄₁NO₂

Melting Point

222-224 degree C

Activity

IGF1R inhibitor

Reconstitution

Soluble in DMSO (40 mg/ml)

Solubilization

May be dissolved in DMSO (25 mg/ml) or ethanol (25 mg/ml)

Preparation and Storage

Store desiccated as supplied at -20 degree C for up to 3 years. Store solutions at -20 degree C for up to 3 months.

Molecular Structure

Related Product Information for Dimethylsphingosine, inhibitor

Sphingosine kinase inhibitor
Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injury (4). Active in vivo.

Scientific Background: A naturally occurring endogenous sphingolipid (1). Inhibits sphingosine kinase (IC₅₀=5 uM) (2). Induces apoptosis in a variety of cell lines (3).

Product Categories/Family for Dimethylsphingosine, inhibitor

Inhibitors; Biochemicals - Kinase Inhibitors

References

1. A Girnita et al. Cancer Res. 2004 64:236 2. A Girnita et al. Clin. Cancer Res. 2006 12:1383 3. E Menu et al. Int. J. Cancer 2007 121:1857 4. A Razuvaev et al. J. Vasc. Surg. 2007 46:108

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Product Notes

The Dimethylsphingosine (Catalog #AAA515070) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dimethylsphingosine, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Dimethylsphingosine, Inhibitor