Structure
CHIR-99021 trihydrochloride, Inhibitor
CHIR-99021 trihydrochloride
Purity
>98% (HPLC)
Synonyms
CHIR-99021 trihydrochloride; CT99021 trihydrochloride; CHIR99021 trihydrochloride; CHIR 99021 trihydrochloride; CT-99021 trihydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
GSK-3
Receptor
GSK-3
Chemical Name
3-Pyridinecarbonitrile, 6-[[2-[[4-(2, 4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-, hydrochloride(1:3)
SMILES
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl
Molecular Formula
C22H21Cl5N8
CAS Number
1782235-14-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CHIR-99021 trihydrochloride, inhibitor
A potent, specific GSK-3 inhibitor with IC50 of 5nM and 10nM for GSK3beta and GSK3alpha, respectively; mimics Wnt signaling in preadipocytes, stabilizes free cytosolic beta-catenin and inhibits adipogenesis by blocking induction of C/EBPalpha and PPARgamma; potentiates insulin activation of glucose transport and utilization in vitro and in vivo; also widely used for stem cell differentiation and naive stem cell generation.
Product Categories/Family for CHIR-99021 trihydrochloride, inhibitor
References
1. Ying QL, et al. Nature. 2008 May 22; 453 (7194):519-23.
2. Ring DB, et al. Diabetes. 2003 Mar; 52 (3):588-95.
3. Bennett CN, et al. J Biol Chem. 2002 Aug 23; 277 (34):30998-1004.
4. Li W, et al. Stem Cells. 2009 Dec; 27 (12):2992-3000.
2. Ring DB, et al. Diabetes. 2003 Mar; 52 (3):588-95.
3. Bennett CN, et al. J Biol Chem. 2002 Aug 23; 277 (34):30998-1004.
4. Li W, et al. Stem Cells. 2009 Dec; 27 (12):2992-3000.
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Product Notes
The CHIR-99021 trihydrochloride (Catalog #AAA3602681) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CHIR-99021 trihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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