Goat anti-Human ANKK1 Polyclonal Antibody | anti-ANKK1 antibody

ANKK1 (Ankyrin repeat and kinase domain containing 1, PKK2, X-kinase, protein kinase PKK2)

Cat. Num. AAA619050

• Gene Names: ANKK1; PKK2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: ANKK1; Polyclonal Antibody; ANKK1 (Ankyrin repeat and kinase domain containing 1; PKK2; X-kinase; protein kinase PKK2); Anti -ANKK1 (Ankyrin repeat and kinase domain containing 1; anti-ANKK1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human ANKK1 at ~85kD.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-ANKK1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:128000; Western Blot: 0.1-0.3ug/ml
• Immunogen: Synthetic peptide with sequence C-SRQADPNLHEAEGKT, from the internal region of human ANKK1 (NP_848605.1).
• Positive Control: Human Brain (Substantia nigra and Amygdala) lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Chemiluminescence

(MBS619050 (0.1ug/ml) staining of Human Substantia Nigra lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-ANKK1 antibody

ANKK1 belongs to the TKL Ser/Thr protein kinase superfamily, contains twelve ANK repeats and one protein kinase domain. The protein is weakly expressed in testis, placenta, and spinal cord.

Product Categories/Family for anti-ANKK1 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 30425444
• NCBI GeneID: 255239
• NCBI Accession #: NP_848605.1
• NCBI GenBank Nucleotide #: NM_178510.1
• UniProt Accession #: Q8NFD2
• Molecular Weight: 84,632 Da
• NCBI Official Full Name: ankyrin repeat and protein kinase domain-containing protein 1
• NCBI Official Synonym Full Names: ankyrin repeat and kinase domain containing 1
• NCBI Official Symbol: ANKK1
• NCBI Official Synonym Symbols: PKK2
• NCBI Protein Information: ankyrin repeat and protein kinase domain-containing protein 1; sgK288; X-kinase; sugen kinase 288; OTTHUMP00000236610; protein kinase PKK2
• UniProt Protein Name: Ankyrin repeat and protein kinase domain-containing protein 1
• Protein Family: Ankyrin repeat and protein kinase domain-containing protein
• UniProt Gene Name: ANKK1
• UniProt Synonym Gene Names: PKK2; SGK288
• UniProt Entry Name: ANKK1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq]

Uniprot Description

ANKK1: belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 11q23.2

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: protein amino acid phosphorylation