Structure
XMD8-87, Inhibitor
XMD8-87
Purity
>98% (HPLC)
Synonyms
XMD8-87; Ack1 inhibitor B19; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 65mg/mL (145.89mM)
Ethanol: 5mg/mL (11.2mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 5mg/mL (11.2mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Ack1 (TNK2)
Receptor
TNK2
Chemical Name
2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5, 11-dihydro-6H-benzo[e]pyrimido[5, 4-b][1, 4]diazepin-6-one
SMILES
C1=NC(NC2=CC=C(N3CCN(C)CC3)C=C2OC)=NC2N(C)C3C=CC=CC=3C(=O)NC1=2
Molecular Formula
C24H27N7O2
CAS Number
1234480-46-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for XMD8-87, inhibitor
XMD8-87 (Ack1 inhibitor B19) is a potent Ack1 inhibitor with Kd of 15nM, inhibits EGF-induced autophosphorylation in HEK293 cells at 2uM; completely inhibits A549 cancer cell growth, and partially inhibited EGF-stimulated cancer cell growth at 10uM; XMD8-87 is a potent, selective Ack1 (TNK2) inhibitor with IC50 of 1.9uM in ELISA assays; potently block proliferation of TNK2 mutant cell lines, shows IC50s of 38nM and 113nM for the D163E and R806Q mutations.
Product Categories/Family for XMD8-87, inhibitor
References
1. Miduturu CV, et al. Chem Biol. 2011 Jul 29; 18 (7):868-79.
2. Mahajan K, et al. Cancer Lett. 2013 Sep 28; 338 (2):185-92.
3. Maxson JE, et al. Cancer Res. 2016 Jan 1; 76 (1):127-38.
2. Mahajan K, et al. Cancer Lett. 2013 Sep 28; 338 (2):185-92.
3. Maxson JE, et al. Cancer Res. 2016 Jan 1; 76 (1):127-38.
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Product Notes
The XMD8-87 (Catalog #AAA3600934) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "XMD8-87, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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