Structure
AT-7519 hydrochloride, Inhibitor
AT-7519 hydrochloride
Purity
>98% (HPLC)
Synonyms
AT-7519 hydrochloride; AT 7519 Hydrochloride; AT7519 Hydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CDK
Receptor
CDK2/CyclinA; CDK4/CyclinD1; CDK5/p35; CDK9/CyclinT; GSK-3beta
Chemical Name
1H-Pyrazole-3-carboxamide, 4-[(2, 6-dichlorobenzoyl)amino]-N-4-piperidinyl-, hydrochloride(1:1)
SMILES
Cl.CC1=C(C(=O)NC2=C(NN=C2)C(=O)NC2CCNCC2)C(Cl)=CC=C1
Molecular Formula
C16H18Cl3N5O2
CAS Number
902135-91-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AT-7519 hydrochloride, inhibitor
A potent CDK2 inhibitor with IC50 of 47nM; also inhibits CDK1/4/5 with IC50 of 190/67/18nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10uM); has antiproliferative activity against HCT116 cells with IC50 of 82nM; exhibits good profile against cytochrome P450 isoforms (
Product Categories/Family for AT-7519 hydrochloride, inhibitor
References
1. Wyatt PG, et al. J Med Chem. 2008 Aug 28; 51 (16):4986-99.
2. Squires MS, et al. Mol Cancer Ther. 2009 Feb; 8 (2):324-32.
3. Dolman ME, et al. Clin Cancer Res. 2015 Nov 15; 21 (22):5100-9.
2. Squires MS, et al. Mol Cancer Ther. 2009 Feb; 8 (2):324-32.
3. Dolman ME, et al. Clin Cancer Res. 2015 Nov 15; 21 (22):5100-9.
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Product Notes
The AT-7519 hydrochloride (Catalog #AAA3606480) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AT-7519 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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