Structure
BAY1082439, inhibitor
BAY1082439
Purity
100.00%
Synonyms
BAY1082439; inhibitor
Purity/Purification
100.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C25H30N6O5
SMILES
COc1c(OC[C@H](O)CN2CCOCC2)ccc2C3=NCCN3C(NC(=O)c3cccnc3C)=Nc12
CAS Number
1375469-38-7
Target & IC50
PI3Kalpha
PI3Kbeta
PI3Kdelta
PI3Kbeta
PI3Kdelta
In Vitro
BAY1082439 (75mg/kg; p.o.; daily for 4 weeks) is effective in preventing Pten-null prostate cancer progression[2].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for BAY1082439, inhibitor
BAY1082439 is a selective and orally bioavailable inhibitor of PI3Kalpha/beta/delta, and also inhibits mutated forms of PIK3CA, with highly effective in inhibiting Pten-null prostate cancer growth.
Product Categories/Family for BAY1082439, inhibitor
References
Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445. AM2012-2799.
Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445. AM2012-2799.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kalpha/beta inhibitor demonstrated potent activity in tumors with activated PI3Kalpha and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445. AM2012-2799.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
Yongkang Zou, et al. Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta inhibitor BAY1082439. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
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Product Notes
The BAY1082439 (Catalog #AAA5754587) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY1082439, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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