Structure
AZ-31, Inhibitor
AZ-31
Purity
>98% (HPLC)
Synonyms
AZ-31; AZ 31; AZ31; inhibitor
Purity/Purification
>98% (HPLC)
Target
ATM/ATR
Receptor
ATM/ATR
Chemical Name
(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide
SMILES
NC(C1=C(N[C@H](C2CCOCC2)C)C3=CC(C4=CN=C(COC)C=C4)=CC=C3N=C1)=O
Molecular Formula
C24H28N4O3
CAS Number
2088113-98-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZ-31, inhibitor
A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2nM, cell IC50 of 46nM; displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kalpha, PI3Kbeta, PI3Kgamma, GSK3beta and KDR; reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice; showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan.
Product Categories/Family for AZ-31, inhibitor
References
1. Degorce SL, et al. J Med Chem. 2016 Jul 14; 59 (13):6281-92.
2. Vendetti FP, et al. Sci Rep. 2017 Feb 1; 7:41892.
3. Kiesel BF, et al. J Pharm Biomed Anal. 2017 May 10; 138:158-165.
2. Vendetti FP, et al. Sci Rep. 2017 Feb 1; 7:41892.
3. Kiesel BF, et al. J Pharm Biomed Anal. 2017 May 10; 138:158-165.
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Product Notes
The AZ-31 (Catalog #AAA3603254) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZ-31, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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