Structure
IQ-1S, Inhibitor
IQ-1S
Purity
>98% (HPLC)
Synonyms
IQ-1S; IQ 1S free acid; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
JNK
Receptor
JNK1; JNK2; JNK3
Chemical Name
11H-Indeno[1, 2-b]quinoxalin-11-one, oxime
SMILES
O/N=C1C2=C(C3=NC4=CC=CC=C4N=C31)C=CC=C2
Molecular Formula
C15H9N3O
CAS Number
23146-22-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for IQ-1S, inhibitor
A potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87nM for JNK1, JNK2, and JNK3, respectively; does not inhibits other kinases that represent potential targets for RA treatment, including GSK-3beta, JAK2, JAK3, PI3Ks, Btk, IKK-2, etc.; inhibits pro-inflammatory cytokine (IL-1alpha, IL-1beta, IL-6, IL-10, TNF-alpha, IFN-gamma, and GM-CSF and nitric oxide production by human and murine monocyte/macrophages; inhibits LPS-induced TNF-alpha and IL-6 production in MonoMac-6 cells with IC50 of 0.25 and 0.61uM, respectively; reduces inflammation and cartilage loss associated with CIA in mice model.
Product Categories/Family for IQ-1S, inhibitor
References
1. Schepetkin IA, et al. Mol Pharmacol. 2012 Jun; 81 (6):832-45.
2. Schepetkin IA, et al. J Pharmacol Exp Ther. 2015 Jun; 353 (3):505-16.
3. Atochin DN, et al. Neurosci Lett. 2016 Apr 8; 618:45-49.
2. Schepetkin IA, et al. J Pharmacol Exp Ther. 2015 Jun; 353 (3):505-16.
3. Atochin DN, et al. Neurosci Lett. 2016 Apr 8; 618:45-49.
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Product Notes
The IQ-1S (Catalog #AAA3603652) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IQ-1S, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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