Rabbit RGS9 Polyclonal Antibody | anti-RGS9 antibody

Anti-RGS9 antibody

Cat. Num. AAA176793

• Gene Names: RGS9; PERRS; RGS9L
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: RGS9; Polyclonal Antibody; Anti-RGS9 antibody; Regulator of G-protein signaling 9; regulator of G-protein signaling 9; PERRS antibody; R9AP antibody; Regulator of G protein signalling 9 antibody; Regulator of G-protein signaling 9 antibody; RGS9 antibody; RGS9_HUMAN antibody; RGS9L antibody; anti-RGS9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 674

• Applicable Applications for anti-RGS9 antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RGS9 (624-638aa LKSKRVANFFQIKMD), different from the related mouse and rat sequences by three amino acids.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-RGS9 antibody, MBS176793, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue Lysate )

Related Product Information for anti-RGS9 antibody

Description: Rabbit IgG polyclonal antibody for Regulator of G-protein signaling 9(RGS9) detection. Tested with WB in Human, Mouse, Rat.
Background: Regulator of G-protein signaling 9, also known as RGS9 is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. This gene is mapped to 17q24.1. This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 8475983
• NCBI GeneID: 8787
• UniProt Accession #: O75916; O75573; Q696R2; Q8TD64; Q8TD65; Q9HC32; Q9HC33; A8K3C0
• Molecular Weight: 76,625 Da
• NCBI Official Full Name: Regulator of G-protein signaling 9
• NCBI Official Synonym Full Names: regulator of G-protein signaling 9
• NCBI Official Symbol: RGS9
• NCBI Official Synonym Symbols: PERRS; RGS9L
• NCBI Protein Information: regulator of G-protein signaling 9; regulator of G-protein signalling 9
• UniProt Protein Name: Regulator of G-protein signaling 9
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS9
• UniProt Synonym Gene Names: RGS9
• UniProt Entry Name: RGS9_HUMAN

NCBI Description

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

RGS9: belongs to the 'regulator of G protein signaling' family. Inhibits signal transduction by increasing the GTPAse activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction. Four alternatively spliced isoforms have been described.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: cytoplasm; plasma membrane; heterotrimeric G-protein complex; nucleus

Molecular Function: signal transducer activity; protein complex binding; GTPase activator activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; nervous system development; regulation of rhodopsin mediated signaling; visual perception; response to estrogen stimulus; dopamine receptor signaling pathway; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

Disease: Prolonged Electroretinal Response Suppression