Molecular Structure
AS-041164, inhibitor
AS-041164
Purity
98% (TLC); NMR (Conforms)
Synonyms
AS-041164; GF-109203X ; 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide; Bisindolylmaleimide I; inhibitor
Purity/Purification
98% (TLC); NMR (Conforms)
Form/Format
Yellow Solid
CAS Number
6318-41-8
Molecular Formula
C11H7NO4S
Activity
PKC inhibitor
Reconstitution
Soluble in dimethyl formamide or DMSO (10mg/ml, warm to 40 degree C)
Solubilization
May be dissolved in DMSO (25 mg/mL)
Preparation and Storage
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20 degree C for 1 month.
Molecular Structure
Molecular Structure
Related Product Information for AS-041164, inhibitor
PI3Kgamma Inhibitor
Potent and selective protein kinase C inhibitor with specificity for the and 1 isotypes. IC50=0.0084, 0.018, 0.210, 0.132 and 0.58 M for, 1,,, and respectively1. An extremely useful tool for assessing the involvement of PKC in various signaling pathways2,3.
Scientific Background: A selective PI 3-Kgamma isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for alpha, beta, gamma and delta isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity (1). Active in vivo.
Potent and selective protein kinase C inhibitor with specificity for the and 1 isotypes. IC50=0.0084, 0.018, 0.210, 0.132 and 0.58 M for, 1,,, and respectively1. An extremely useful tool for assessing the involvement of PKC in various signaling pathways2,3.
Scientific Background: A selective PI 3-Kgamma isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for alpha, beta, gamma and delta isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity (1). Active in vivo.
Product Categories/Family for AS-041164, inhibitor
References
D Toullec et al. J. Biol. Chem. 1991 266:15771
2. T Bouschet et al. J. Biol. Chem. 2003 278:4778
3. G Robert et al. PLoS One 2009 4:e7889
2. T Bouschet et al. J. Biol. Chem. 2003 278:4778
3. G Robert et al. PLoS One 2009 4:e7889
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Product Notes
The AS-041164 (Catalog #AAA515050) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AS-041164, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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