Structure
ARQ 621, Inhibitor
ARQ 621
Purity
>98% (HPLC)
Synonyms
ARQ 621; ARQ621; ARQ-621; inhibitor
Purity/Purification
>98% (HPLC)
Target
BACE
Receptor
Eg5 mitotic motor protein
Chemical Name
(R)-N-(3-aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3, 4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide
SMILES
NCCCN([C@H](CC#C)C1=NC2=C(C=CC(Cl)=C2)C(=O)N1NC1=CC=CC=C1)C(=O)C1=CC=CC(Cl)=C1F
Molecular Formula
C28H24Cl2FN5O2
CAS Number
1095253-39-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ARQ 621, inhibitor
ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies.
Product Categories/Family for ARQ 621, inhibitor
References
1. Rosen L, et al. Annual Meeting of ASCO: abstract 3076
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Product Notes
The ARQ 621 (Catalog #AAA3607136) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ARQ 621, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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