Testing Data
ABT-751, inhibitor
ABT-751
Purity
>99%
Synonyms
ABT-751; inhibitor
Purity/Purification
>99%
Solubility
DMSO >=74mg/mL - Water <1mg/mL - Ethanol >=15mg/mL
Formula
C18H17N3O4S
CAS Number
141430-65-1
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for ABT-751, inhibitor
ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 uM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. In preclinical studies, ABT-751 showed antitumor activity against a broad spectrum of tumor lines and human xenograft models (colon, nasopharyngeal, lung, stomach, breast, pancreas, prostate). ABT-751 is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. ABT-751 also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. ABT-751 is currently under clinical development for cancer treatment. [1][2][3][4]
Product Categories/Family for ABT-751, inhibitor
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Product Notes
The ABT-751 (Catalog #AAA8506497) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ABT-751, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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