3BDO, inhibitor

3BDO

Cat. Num. AAA5754430

• Purity: 98.00%
• Synonyms: 3BDO; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 150mg/mL (458.25mM); (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C18H17NO5
• SMILES: O=C1OC(COC2=C([N+]([O-])=O)C=CC=C2)CC1CC3=CC=CC=C3
• CAS Number: 890405-51-3
• Target & IC50: mTOR
• In Vitro: Immunofluorescence assay reveals that 3BDO treatment,increases the level of p-p70S6K and decreases the protein level of ATG13 in plaque endothelium of mice. 3BDO does not affect the phosphorylation of mTOR direct downstream targets p70S6K and 4EBP1. As compare with controls, apoE-/- mice show inhibited endothelium autophagy and apoptosis with 3BDO treatment, so 3BDO protects against endothelium injury in atherosclerosis. 3BDO treatment,stabilizes established atherosclerotic lesions in apoE-/- mice. In apoE-/-mice, as compare with controls, with 3BDO treatment, the serum level of IL-6 and IL-8 is significantly decreased[2].
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for 3BDO, inhibitor

3BDO is an activator of mTOR. It can also inhibit autophagy..

Product Categories/Family for 3BDO, inhibitor

PI3K/Akt/mTOR signaling; mTOR

References

Ge D, et al. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71.
Ge D, et al. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71.
Peng N, et al. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E/ mice. Sci Rep. 2014 Jul 1;4:5519.
Peng N, et al. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E/ mice. Sci Rep. 2014 Jul 1;4:5519.