Structure
Alkannin, Inhibitor
Alkannin
Purity
98.00%
Synonyms
Alkannin; Shikonin; inhibitor
Purity/Purification
98.00%
Form/Format
Powder
Formula
C16H16O5
CAS
517-88-4
Smiles
C\C(C)=C\C[C@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Receptor (IC50)
PI3Kalpha
Solubility
DMSO: 10mM
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Preparation and Storage
Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Structure
Structure
Related Product Information for Alkannin, inhibitor
Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-kappaB-mediated pathway.
Product Categories/Family for Alkannin, inhibitor
References
1. Takano-Ohmuro H, Yoshida L S, Yuda Y, et al. Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity[J]. Inflammation Research, 2008, 57 (10):484-488.
2. Liu J P, Liu D, Gu J F, et al. Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC?803 via the Toll?like receptor 2/nuclear factor?kappa B pathway[J]. Journal of Pharmacy & Pharmacology, 2015, 67 (8):1143-1155.
3. Gara R K, Srivastava V K, Duggal S, et al. Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway[J]. Journal of Biomedical Science, 2015, 22 (1):26.
4. Qu D, Xu X, Zhang M, et al. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Molecular Medicine Reports, 2015.
2. Liu J P, Liu D, Gu J F, et al. Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC?803 via the Toll?like receptor 2/nuclear factor?kappa B pathway[J]. Journal of Pharmacy & Pharmacology, 2015, 67 (8):1143-1155.
3. Gara R K, Srivastava V K, Duggal S, et al. Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway[J]. Journal of Biomedical Science, 2015, 22 (1):26.
4. Qu D, Xu X, Zhang M, et al. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Molecular Medicine Reports, 2015.
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Product Notes
The Alkannin (Catalog #AAA5751427) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Alkannin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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