Interleukin 23 (IL23) Recombinant Protein | IL23 recombinant protein

Recombinant Interleukin 23 (IL23)

Cat. Num. AAA2097536

• Gene Names: Il23a; p19; IL-23
• Reactivity: Mouse
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Interleukin 23 (IL23); Recombinant Interleukin 23 (IL23); IL23A; P19; IL23P19; SGRF; Interleukin-23 subunit alpha; IL23 recombinant protein

• Reactivity: Mouse
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 196

• Applicable Applications for IL23 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: Two N-terminal Tags, His-tag and SUMO-tag
• Buffer Formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Met1~Ala196
• Subcellular Location: Secreted
• Isoelectric Point: 5.8

Sequence Information

SDS-Page

Testing Data

Product Categories/Family for IL23 recombinant protein

Cytokine; Tumor immunity; Infection immunity

NCBI and Uniprot Product Information

• NCBI GI #: 13752579
• NCBI GeneID: 83430
• NCBI Accession #: NP_112542.1
• NCBI GenBank Nucleotide #: NP_112542.1
• UniProt Accession #: Q9EQ14
• Molecular Weight: Predicted Molecular Weight: 35.8kDa; Accurate Molecular Weight: 36kDa
• NCBI Official Full Name: interleukin-23 subunit alpha
• NCBI Official Synonym Full Names: interleukin 23, alpha subunit p19
• NCBI Official Symbol: Il23a
• NCBI Official Synonym Symbols: p19; IL-23
• NCBI Protein Information: interleukin-23 subunit alpha
• UniProt Protein Name: Interleukin-23 subunit alpha
• UniProt Gene Name: Il23a
• UniProt Synonym Gene Names: IL-23 subunit alpha; IL-23-A; IL-23p19

Uniprot Description

IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10|10 D3

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-23 receptor binding; protein binding

Biological Process: defense response to Gram-negative bacterium; defense response to virus; immune response; immune system process; inflammatory response; innate immune response; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; regulation of tyrosine phosphorylation of STAT protein; T cell proliferation; tissue remodeling