IL-2 Superkine Recombinant Protein
IL-2 Superkine (Fc), IL-2:Fc, Recombinant, Human (IL-2 Superkine (human):Fc (human) (rec.), Interleukin-2, T Cell Growth Factor, TCGF, Aldesleukin, Super-2)
Purity
Highly Purified>95% (SDS-PAGE)
Synonyms
IL-2 Superkine; IL-2 Superkine (Fc); IL-2:Fc; Recombinant; Human (IL-2 Superkine (human):Fc (human) (rec.); Interleukin-2; T Cell Growth Factor; TCGF; Aldesleukin; Super-2); IL-2 Superkine recombinant protein
Host
Human, HEK 293 cells
Specificity
Binds to human and mouse IL-2R.
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
>95% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Sequence
The extracellular domain of human IL-2 (aa 21-153) (mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F) is fused at the C-terminus to the Fc portion of human IgG2.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Stable for at least 1 year after receipt when stored at -20 degree C. Working aliquots are stable for up to 3 months when stored at -20 degree C.
Long-term Storage: -20 degree C
Stable for at least 1 year after receipt when stored at -20 degree C. Working aliquots are stable for up to 3 months when stored at -20 degree C.
Related Product Information for IL-2 Superkine recombinant protein
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens. IL-2 promotes T cell proliferation and particularly naive T cells. IL-2 signaling on activated T cells is effected through a quaternary high-affinity receptor complex consisting of IL-2, IL-2Ralpha (CD25), IL-2Rbeta and IL-2Rgamma. Naive T cells are relatively insensitive to IL-2 as they only express small amounts of IL-2Rbeta and IL-2Rgamma. They only acquire sensitivity after CD25 expression, which captures the cytokine and presents it to the IL-2Rbeta and IL-2Rgamma receptors. IL-2 Superkine (Fc) is an artificial variant of IL-2 containing mutations at positions L80F / R81D / L85V / I 86V / I92F. These mutations are located in the molecule's core that acts to stabilize the structure and to give it a receptor-binding conformation mimicking native IL-2 bound to CD25. These mutations effectively eliminate the functional requirement of IL-2 for CD25 expression and elicit proliferation of T cells. Compared to IL-2, the IL-2 superkine induces superior expansion of cytotoxic T cells, leading to improved antitumour responses in vivo, and elicits proportionally less toxicity by lowering the expansion of Tregulatory cells and reducing pulmonary oedema.
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Product Notes
The IL-2 Superkine (Catalog #AAA635491) is a Recombinant Protein produced from Human, HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The extracellu lar domain of human IL-2 (aa 21-153) (mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F) is fused at the C-terminus to the Fc portion of human IgG2. It is sometimes possible for the material contained within the vial of "IL-2 Superkine, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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