Interleukin 20 Recombinant Protein | IL20Ra recombinant protein

Recombinant Interleukin 20 Receptor Alpha (IL20Ra)

Cat. Num. AAA2029935

• Gene Names: IL20; IL-20; IL10D; ZCYTO10
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Interleukin 20; Recombinant Interleukin 20 Receptor Alpha (IL20Ra); IL20Ra recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- YSAYRYIQ VGKEKHPANL VLIYRNEIGK RVFNPTETLH SITLSTLDDS KISQTDMNLL DRSSDEVSVN NPEFSGSWEP NWEDAEGQHL GYSSHLVDIV CGVEQSDRDT SLTQHAWFNS PMPTGEADFE PQYKVLADFY KEGRDQQFCG SEEAARTEKL AEPQATLANL DPQLEDLQHL GQEHPGSEAR PEEEASTTLV DWDPRTGRLC IPSLPIFGHD LENYGCYERD HLSEDGLLSR LYENQAPDKSEEENENYLIQ FMEEWGLHVQ MES
• Sequence Length: 176

• Applicable Applications for IL20Ra recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 34.8kDa
• Accurate Molecular Mass (KD): 44kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: N-terminal His-Tag, T7 tag
• Organism Species: Rattus norvegicus (Rat)
• Fragment: Tyr273~Ser543
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 109658898
• NCBI GeneID: 50604
• Molecular Weight: 17,144 Da
• NCBI Official Full Name: Interleukin 20
• NCBI Official Synonym Full Names: interleukin 20
• NCBI Official Symbol: IL20
• NCBI Official Synonym Symbols: IL-20; IL10D; ZCYTO10
• NCBI Protein Information: interleukin-20
• UniProt Protein Name: Interleukin-20
• Protein Family: Interleukin-20 receptor
• UniProt Gene Name: IL20
• UniProt Synonym Gene Names: ZCYTO10; IL-20
• UniProt Entry Name: IL20_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Uniprot Description

IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-20 receptor binding; interleukin-22 receptor binding; cytokine activity

Biological Process: positive regulation of osteoclast differentiation; regulation of inflammatory response; positive regulation of epidermal cell differentiation; positive regulation of JAK-STAT cascade; immune response; inflammatory response; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of keratinocyte differentiation