IL-2 active protein

Human IL-2

Cat. Num. AAA691721

• Gene Names: IL2; IL-2; TCGF; lymphokine
• Reactivity: Human
• Purity: > 98% by SDS-PAGE & silver stain
• Synonyms: IL-2; Human IL-2; Recombinant Human Interleukin-2; Interleukin-2; T-cell growth factor; IL-2 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE & silver stain
• Form/Format: Lyophilized
• Sequence: N-Terminal Sequence: APTSSSTK and MAPTSSST
• Sequence Length: 134

• Endotoxin Level: < 0.1ng per ìg (IEU/ug) of rh IL-2
• Buffer: 50 mM acetic acid
• Preparation and Storage: The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0 degree C. Reconstituted IL-2 should be stored in workingaliquots at -20 degree C. Avoid repeated freeze-thaw cycles.

Testing Data

Testing Data #2

Related Product Information for IL-2 active protein

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.

Product Categories/Family for IL-2 active protein

Cytokines & Growth Factors

References

1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. 2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. 3. Taniguchi, T. et al. (1983) Nature 302:305. 4. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. 5. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. 6. Wang, X. et al. (2005) Science 310:1159. 7. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. 8. Jaleco, S. et al. (2003) J. Immunol. 171:61. 9. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.

NCBI and Uniprot Product Information

• NCBI GI #: 28178861
• NCBI GeneID: 3558
• NCBI Accession #: NP_000577
• NCBI GenBank Nucleotide #: NM_000586
• UniProt Accession #: P60568; P01585
• Molecular Weight: 15.5 kDa
• NCBI Official Full Name: interleukin-2
• NCBI Official Synonym Full Names: interleukin 2
• NCBI Official Symbol: IL2
• NCBI Official Synonym Symbols: IL-2; TCGF; lymphokine
• NCBI Protein Information: interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion
• UniProt Protein Name: Interleukin-2
• UniProt Gene Name: IL2
• UniProt Synonym Gene Names: IL-2; TCGF
• UniProt Entry Name: IL2_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location: Secreted.

Involvement in disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Pharmaceutical use: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Sequence similarities: Belongs to the IL-2 family.

Sequence caution: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.