Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium voltage-gated channel subfamily A member 2 (KCNA2) Standard Curve.)
Human Potassium Voltage-Gated Channel Subfamily A Member 2 (KCNA2) ELISA Kit | KCNA2 elisa kit
Human Potassium Voltage-Gated Channel Subfamily A Member 2 (KCNA2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium voltage-gated channel subfamily A member 2 (KCNA2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Potassium voltage-gated channel subfamily A member 2 (KCNA2) Standard Curve.)
Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). KCNA2 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of KCNA2 is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
NCBI and Uniprot Product Information
NCBI Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv1.2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p13
Cellular Component: axon; cell junction; dendrite; endoplasmic reticulum membrane; integral to plasma membrane; lamellipodium; nerve terminal; perikaryon; plasma membrane; presynaptic membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process: generation of action potential; optic nerve structural organization; potassium ion transport; protein homooligomerization; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of dopamine secretion; sensory perception of pain
Disease: Epileptic Encephalopathy, Early Infantile, 32
Research Articles on KCNA2
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Product Notes
The Human KCNA2 kcna2 (Catalog #AAA9715593) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715593 ELISA Kit recognizes Human KCNA2. It is sometimes possible for the material contained within the vial of "Potassium Voltage-Gated Channel Subfamily A Member 2 (KCNA2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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