Human DPP6/Dipeptidyl Aminopeptidase-Like Protein 6 ELISA Kit | DPP6 elisa kit

Human DPP6/Dipeptidyl Aminopeptidase-Like Protein 6 ELISA Kit

Cat. Num. AAA2889847

• Gene Names: DPP6; VF2; DPL1; DPPX; MRD33
• Reactivity: Human
• Synonyms: DPP6/Dipeptidyl Aminopeptidase-Like Protein 6; Human DPP6/Dipeptidyl Aminopeptidase-Like Protein 6 ELISA Kit; Dipeptidyl aminopeptidase-like protein 6; DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI; DPP VI; DPP6 elisa kit

• Reactivity: Human
• Specificity: Natural and recombinant Human Dipeptidyl aminopeptidase-like protein 6
• Sequence Length: 865

• Assay Type: Sandwich
• Detection Range: 1.56-100ng/mL
• Sensitivity: 0.77ng/mL
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 218512016
• NCBI GeneID: 1804
• UniProt Accession #: P42658
• NCBI Official Full Name: Dipeptidyl aminopeptidase-like protein 6
• NCBI Official Synonym Full Names: dipeptidyl peptidase like 6
• NCBI Official Symbol: DPP6
• NCBI Official Synonym Symbols: VF2; DPL1; DPPX; MRD33
• NCBI Protein Information: dipeptidyl aminopeptidase-like protein 6
• UniProt Protein Name: Dipeptidyl aminopeptidase-like protein 6
• Protein Family: Dipeptidyl aminopeptidase-like protein
• UniProt Gene Name: DPP6
• UniProt Synonym Gene Names: DPP VI
• UniProt Entry Name: DPP6_HUMAN

NCBI Description

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

DPP6: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2). A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36.2

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: potassium channel regulator activity; serine-type peptidase activity; dipeptidyl-peptidase activity

Biological Process: generation of action potential; proteolysis

Disease: Ventricular Fibrillation, Paroxysmal Familial, 2; Mental Retardation, Autosomal Dominant 33