No significant cross-reactivity or interference between Pim-2 Oncogene (PIM2) and analogues was observed.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
Uniprot Description
Pim2: a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Oncoprotein; EC 2.7.11.1; Protein kinase, CAMK; CAMK group; PIM family
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; ATP binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; response to virus; regulation of mitotic cell cycle; male meiosis; protein amino acid phosphorylation; negative regulation of cell proliferation; cell proliferation; apoptotic mitochondrial changes; positive regulation of autophagy; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PIM2
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Product Notes
The Human PIM2 pim2 (Catalog #AAA2001108) is a CLIA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2001108 CLIA Kit recognizes Human PIM2. It is sometimes possible for the material contained within the vial of "Pim-2 Oncogene (PIM2), CLIA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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