STRUCTURE
(Chemical structure of Tafamidis (SIH-584), a TTR kinetic stabilizer. CAS #: 594839-88-0. Molecular Formula: C14H7Cl2NO3. Molecular Weight: 308.1 g/mol.)
Tafamidis, Inhibitor
Tafamidis
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Tafamidis; Transthyretin Dissociation Inhibitor; 2-(3; 5-Dichlorophenyl)-1; 3-Benzoxazole-6-Carboxylic Acid; FX-1006; 5-Dichlorophenyl)-6-benzoxazole carboxylic acid; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Off-white powder
Source
Synthetic
Molecular Formula
C14H7Cl2NO3
Solubility
May be dissolved in DMSO (25 mg/ml, warm)
SMILES
C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey
TXEIIPDJKFWEEC-UHFFFAOYSA-N
PubChem CID
11001318
CAS No.
594839-88-0
Preparation and Storage
Store at -20 degree C
Shipping Temperature: Shipped Ambient
Shipping Temperature: Shipped Ambient
STRUCTURE
(Chemical structure of Tafamidis (SIH-584), a TTR kinetic stabilizer. CAS #: 594839-88-0. Molecular Formula: C14H7Cl2NO3. Molecular Weight: 308.1 g/mol.)
STRUCTURE
(Chemical structure of Tafamidis (SIH-584), a TTR kinetic stabilizer. CAS #: 594839-88-0. Molecular Formula: C14H7Cl2NO3. Molecular Weight: 308.1 g/mol.)
Related Product Information for Tafamidis, inhibitor
Background: Tafamidis functions as a chaperone that stabilizes the correctly folded tetrameric form of the transthyretin (TTR) protein by binding in one of the two thyroxine-binding sites of the tetramer (1). In drug form, it is used to delay impairment of peripheral nerve function in adults with familial amyloid polyneuropathy.
Product Categories/Family for Tafamidis, inhibitor
References
1. Said G, Grippon S, Kirkpatrick P. (2012). Nature Reviews. Drug Discovery. 11(3): 185-186.
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Product Notes
The Tafamidis (Catalog #AAA8005725) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tafamidis, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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