Poliovirus Receptor-Related Protein 2 Active Protein | Nectin2 active protein

Recombinant Mouse Poliovirus Receptor-Related Protein 2

Cat. Num. AAA2556784

• Gene Names: Nectin2; MPH; Pvr; Pvs; Cd112; Pvrl2; AI325026; AI987993; nectin-2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Poliovirus Receptor-Related Protein 2; Recombinant Mouse Poliovirus Receptor-Related Protein 2; CD112; nectin2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Murine herpes virus entry protein B; mHveB; Poliovirus receptor homolog; Poliovirus receptor-related protein 2; Pvrl2; Nectin2 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 530

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Gly 351
• Fusion Tag: C-6His
• Activity: Measured by its binding ability in a functional ELISA.1. Immobilized mouse CD112-His at 10 mug/ml (100 mul/well) can bind biotinylated mouse DNAM1-His with a linear range of 0.156-5.0 mug/ml. 2. Immobilized mouse CD112-His at 10 mug/ml (100 mul/well) can bind mouse DNAM1-Fc with a linear range of 0.03-1.0 mug/ml.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Nectin2 active protein

Protein Construction: Recombinant Mouse Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Gly351 is expressed with a 6His tag at the C-terminus.

Background: Nectin-2(CD112) is a member of the nectin family, which contains two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. Nectins are type I transmembrane glycoproteins that are calcium-independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs). Nectin2 is widely expressed in human tissues including brain, spinal cord, spleen, kidney, heart and liver. It can form trans-heterodimers with PVRL3/nectin-3 and interacts with CD226. Mutations of alleles of the murine CD112 gene can result in conditions such as morphologically aberrant spermatozoa. It may function in allergic reactions, and accordingly may used as a novel target for anti-allergic therapy.

NCBI and Uniprot Product Information

• NCBI GI #: 228480273
• NCBI GeneID: 19294
• NCBI Accession #: NP_033016.3
• NCBI GenBank Nucleotide #: NM_008990.3
• UniProt Accession #: P32507; Q62096
• Molecular Weight: Molecular Mass: 35.6kDa; Actual Protein Molecular Mass: 40-45kDa
• NCBI Official Full Name: nectin-2 isoform 1
• NCBI Official Synonym Full Names: nectin cell adhesion molecule 2
• NCBI Official Symbol: Nectin2
• NCBI Official Synonym Symbols: MPH; Pvr; Pvs; Cd112; Pvrl2; AI325026; AI987993; nectin-2
• NCBI Protein Information: nectin-2
• UniProt Protein Name: Nectin-2
• Protein Family: Nectin
• UniProt Gene Name: Nectin2
• UniProt Synonym Gene Names: Mph; Pvr; Pvrl2; Pvs; Herpesvirus entry mediator B; HveB; mHveB

Uniprot Description

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.