Western Blot (WB)
(Western blot analysis Phospho-IRF-7 (Ser437/Ser438) using Mouse slpeen tissue lysates. -/+ means absence or presence of N peptide（non-phospho peptide) and P peptide(phospho peptide).)
Rabbit anti-Human, Mouse IRF-7 Polyclonal Antibody | anti-IRF-7 antibody
Phospho-IRF-7 (Ser437/Ser438) Antibody
Peptide ELISA: 1:20,000-1:40,000
Western Blot (WB)
(Western blot analysis Phospho-IRF-7 (Ser437/Ser438) using Mouse slpeen tissue lysates. -/+ means absence or presence of N peptide（non-phospho peptide) and P peptide(phospho peptide).)
Western Blot (WB)
(Western blot analysis Phospho-IRF-7 (Ser437/Ser438) using Mouse slpeen tissue lysates. -/+ means absence or presence of N peptide（non-phospho peptide) and P peptide(phospho peptide).)
NCBI and Uniprot Product Information
Uniprot Description
IRF7: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome- dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6. By type I interferon (IFN) and viruses. Expressed predominantly in spleen, thymus and peripheral blood leukocytes. In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA- binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; transcription, DNA-dependent; immune system process; positive regulation of transcription, DNA-dependent; interferon-alpha production; regulation of MyD88-dependent toll-like receptor signaling pathway; regulation of innate immune response; regulation of transcription from RNA polymerase II promoter; regulation of adaptive immune response; regulation of MyD88-independent toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; positive regulation of interferon-beta production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immunoglobulin mediated immune response; interferon type I biosynthetic process; interferon-beta production; positive regulation of interferon-alpha production
Research Articles on IRF-7
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Product Notes
The IRF-7 irf7 (Catalog #AAA9612954) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-IRF-7 (Ser437/Ser438) Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IRF-7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Peptide ELISA (EIA). WB: 1:500-1:2000 Peptide ELISA: 1:20,000-1:40,000. Researchers should empirically determine the suitability of the IRF-7 irf7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRF-7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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