human immunodeficiency virus type I enhancer binding protein 1 ELISA Kit | HIVEP1 elisa kit

Human Zinc finger protein 40, HIVEP1 ELISA Kit

Cat. Num. AAA9339112

• Gene Names: HIVEP1; GAAP; ZAS1; CIRIP; MBP-1; ZNF40; CRYBP1; ZNF40A; PRDII-BF1; Schnurri-1
• Reactivity: Human
• Synonyms: human immunodeficiency virus type I enhancer binding protein 1; Human Zinc finger protein 40; HIVEP1 ELISA Kit; Human Zinc finger protein 40 (HIVEP1) ELISA kit; RP3-451B15.2; CIRIP; CRYBP1; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A; Zinc finger protein 40 (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatib; HIVEP1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 613410170
• NCBI GeneID: 3096
• NCBI Accession #: NP_002105.3
• NCBI GenBank Nucleotide #: NM_002114.3
• UniProt Accession #: P15822; Q14122; Q5MPB1; Q5VW60; B2RTU3
• Molecular Weight: 296,865 Da
• NCBI Official Full Name: zinc finger protein 40
• NCBI Official Synonym Full Names: human immunodeficiency virus type I enhancer binding protein 1
• NCBI Official Symbol: HIVEP1
• NCBI Official Synonym Symbols: GAAP; ZAS1; CIRIP; MBP-1; ZNF40; CRYBP1; ZNF40A; PRDII-BF1; Schnurri-1
• NCBI Protein Information: zinc finger protein 40; cirhin interaction protein; gate keeper of apoptosis-activating protein; positive regulatory domain II binding factor 1; major histocompatibility complex binding protein 1
• UniProt Protein Name: Zinc finger protein 40
• Protein Family: Zinc finger protein
• UniProt Gene Name: HIVEP1
• UniProt Synonym Gene Names: ZNF40; CIRIP; GAAP; HIV-EP1; MBP-1; PRDII-BF1
• UniProt Entry Name: ZEP1_HUMAN

NCBI Description

This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

Uniprot Description

HIVEP1: This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 6p24-p22.3

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter