LYPD3 active protein

LYPD3 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122814

• Gene Names: Lypd3; C4.4a; 2310061G07Rik
• Purity: >92% as determined by SDS-PAGE
• Synonyms: LYPD3; LYPD3 Protein; Mouse; Recombinant (His Tag); Mouse C4.4A/LYPD3 Protein (His Tag); 2310061G07Rik Protein; C4.4a Protein; LY6/PLAUR domain containing 3; LYPD3 active protein

• Host: HEK293 Cells
• Purity/Purification: >92% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-His287

• Species: Mouse
• Activity: Measured by its ability to bind recombinant human Galectin3 in a functional ELISA.
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Leu 33
• Tag: C-His
• Protein Construction: A DNA sequence encoding the N-terminal segment of mouse LYPD3 (NP_598504.1)(Met 1-His 287) was expressed, with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LYPD3 active protein

Background: Ly6/PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4, and LYPD3, is a cell membrane protein that contains two UPAR/Ly6 domains. Human LYPD3 contains two UPAR/Ly6 domains. LYPD3 is expressed in the placenta, skin, and urothelium. It is found in suprabasal keratinocytes of chronic wounds. Weak expression of LYPD3 is found in the esophagus and peripheral blood mononuclear cells. It is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression of LYPD3 is found in the tumor component of some noninvasive superficial lesions and invasive and metastatic urothelial cancers. LYPD3 is up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds. LYPD3 supports cell migration. It may be involved in urothelial cell-matrix interactions. It may also be involved in tumor progression

References

Smith B.A., et al., 2001, Cancer Res. 61:1678-85. Wuerfel J., et al., 2001, Gene 262:35-41. Clark H.F., et al., 2003, Genome Res. 13:2265-70. Fletcher G.C., et al., 2003, Br. J. Cancer 88:579-85. Hansen L.V., et al., 2004, Biochem. Eng. J. 380:845-57.

NCBI and Uniprot Product Information

• NCBI GI #: 19526946
• NCBI GeneID: 72434
• NCBI Accession #: NP_598504.1
• NCBI GenBank Nucleotide #: NM_133743.1
• UniProt Accession #: Q91YK8
• Molecular Weight: 37,489 Da
• NCBI Official Full Name: ly6/PLAUR domain-containing protein 3
• NCBI Official Synonym Full Names: Ly6/Plaur domain containing 3
• NCBI Official Symbol: Lypd3
• NCBI Official Synonym Symbols: C4.4a; 2310061G07Rik
• NCBI Protein Information: ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein homolog; GPI-anchored metastasis-associated protein C4.4A homolog
• UniProt Protein Name: Ly6/PLAUR domain-containing protein 3
• Protein Family: Ly6/PLAUR domain-containing protein
• UniProt Gene Name: Lypd3
• UniProt Synonym Gene Names: C4.4a
• UniProt Entry Name: LYPD3_MOUSE