SDS-Page
LRRC32/GARP Active Protein | LRRC32 active protein
Human CellExp LRRC32/GARP, Fc Tag, Human Recombinant
Gene Names
LRRC32; GARP; D11S833E
Purity
>95% by SDS-PAGE
Synonyms
LRRC32/GARP; Human CellExp LRRC32/GARP; Fc Tag; Human Recombinant; GARP; Garpin; D11S833E; Glycoprotein A repetitions predominant; LRRC32 active protein
Host
HEK293 cells
Purity/Purification
>95% by SDS-PAGE
Form/Format
Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Gene Source
Human
Endotoxin
<1.0 EU per/ug
Biological Activity
Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
Measured by its binding ability in a functional ELISA.
Measured by its binding ability in a functional ELISA.
Reconstitution Instruction
Reconstitute in sterile deionized water to the desired protein concentration.
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Centrifuge the vial prior to opening.
Shelf life: ~12 months
SDS-Page
SDS-Page
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for LRRC32 active protein
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
Product Categories/Family for LRRC32 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
71,979 Da
NCBI Official Full Name
Leucine-rich repeat-containing protein 32
NCBI Official Synonym Full Names
leucine rich repeat containing 32
NCBI Official Symbol
LRRC32
NCBI Official Synonym Symbols
GARP; D11S833E
NCBI Protein Information
leucine-rich repeat-containing protein 32
UniProt Protein Name
Leucine-rich repeat-containing protein 32
Protein Family
UniProt Gene Name
LRRC32
UniProt Synonym Gene Names
D11S833E; GARP; GARP
UniProt Entry Name
LRC32_HUMAN
NCBI Description
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]
Uniprot Description
LRRC32:
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13.5-q14
Cellular Component: integral to plasma membrane
Research Articles on LRRC32
1. GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells.
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Product Notes
The LRRC32 lrrc32 (Catalog #AAA849834) is an Active Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LRRC32/GARP, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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