Guinea Pig Mediator of DNA damage checkpoint protein 1 (MDC1) ELISA Kit | MDC1 elisa kit
Guinea pig Mediator of DNA damage checkpoint protein 1 (MDC1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Uniprot Description
MDC1: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; focal adhesion; chromosome; nucleus
Molecular Function: protein C-terminus binding; protein binding
Biological Process: intra-S DNA damage checkpoint; double-strand break repair; DNA repair; double-strand break repair via homologous recombination
Research Articles on MDC1
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Product Notes
The Guinea Pig MDC1 mdc1 (Catalog #AAA7238086) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7238086 ELISA Kit recognizes Guinea Pig MDC1. It is sometimes possible for the material contained within the vial of "Mediator of DNA damage checkpoint protein 1 (MDC1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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