Typical Testing Data/Standard Curve (for reference only)
Mouse Gremlin 2 ELISA Kit | GREM2 elisa kit
Mouse Gremlin 2 ELISA Kit
Gene Names
Grem2; Prdc; Gremlin2
Reactivity
Mouse
Synonyms
Gremlin 2; Mouse Gremlin 2 ELISA Kit; CKTSF1B2; DAND3; PRDC; Gremlin-2; Cysteine knot superfamily 1; BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus; GREM2 elisa kit
Reactivity
Mouse
Specificity
The Mouse Gremlin 2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Mouse Gremlin 2 proteins within the range of 31.2 pg/ml - 2000 pg/ml.
Sequence Length
168
Samples
Cell Culture Supernates, Serum, Plasma
Sensitivity
<10 pg/ml
Preparation and Storage
Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for GREM2 elisa kit
Principle of the Assay: The Mouse Gremlin 2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Mouse Gremlin 2 in Cell Culture Supernates, Serum, Plasma. This assay employs an antibody specific for Mouse Gremlin 2 coated on a 96-well plate. Standards and samples are pipetted into the wells and Gremlin 2 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Mouse Gremlin 2 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of Gremlin 2 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.
Background: GREM2, also known as PRDC, is one of several BMP antagonists that regulate the functions of BMPs during embryonic development and tissue differentiation. BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. The PRDC gene is mapped to chromosome 1q43.
Background: GREM2, also known as PRDC, is one of several BMP antagonists that regulate the functions of BMPs during embryonic development and tissue differentiation. BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. The PRDC gene is mapped to chromosome 1q43.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19,334 Da
NCBI Official Full Name
gremlin-2
NCBI Official Synonym Full Names
gremlin 2, DAN family BMP antagonist
NCBI Official Symbol
Grem2
NCBI Official Synonym Symbols
Prdc; Gremlin2
NCBI Protein Information
gremlin-2
UniProt Protein Name
Gremlin-2
Protein Family
UniProt Gene Name
Grem2
UniProt Synonym Gene Names
Cktsf1b2; Prdc; PRDC
UniProt Entry Name
GREM2_MOUSE
Uniprot Description
GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space
Molecular Function: heparin binding; protein homodimerization activity
Biological Process: cytokine and chemokine mediated signaling pathway; determination of dorsal identity; embryonic body morphogenesis; negative regulation of BMP signaling pathway
Research Articles on GREM2
Similar Products
Product Notes
The Mouse GREM2 grem2 (Catalog #AAA8248440) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8248440 ELISA Kit recognizes Mouse GREM2. It is sometimes possible for the material contained within the vial of "Gremlin 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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