GREM2 elisa kit
Rabbit GREM2 PicoKine ELISA Kit
Gene Names
GREM2; PRDC; DAND3; STHAG9; CKTSF1B2
Reactivity
RabbitThere is no detectable cross-reactivity with other relevant proteins.
Applications
ELISA
Synonyms
GREM2; Rabbit GREM2 PicoKine ELISA Kit; Gremlin-2; Cysteine knot superfamily 1; BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus; CKTSF1B2; DAND3; PRDC; GREM2 elisa kit
Reactivity
Rabbit
There is no detectable cross-reactivity with other relevant proteins.
There is no detectable cross-reactivity with other relevant proteins.
Specificity
Natural and recombinant Rabbit Rabbit GREM2
Sequence Length
168
Applicable Applications for GREM2 elisa kit
ELISA (EIA)
Assay Type
Quantitative Sandwich
Detection Range
62.5pg/ml-4000pg/ml
Sensitivity
<12pg/ml
Intra-assay Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-assay Precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Preparation and Storage
Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles.
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for GREM2 elisa kit
Principle of the Assay: Rabbit Rabbit GREM2 ELISA Kit was based on standard sandwich enzyme-linked immune- sorbent assay technology. A specific for Rabbit GREM2 has been precoated onto 96-well plates. Standards(Expression system for standard: E.coli; Immunogen sequence: R22-Q168) and test samples are added to the wells, a biotinylated detection specific for Rabbit GREM2 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Rabbit Rabbit GREM2 amount of sample captured in plate.
Background: GREM2, also known as PRDC, is one of several BMP antagonists that regulate the functions of BMPs during embryonic development and tissue differentiation. BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. The PRDC gene is mapped to chromosome 1q43.
Background: GREM2, also known as PRDC, is one of several BMP antagonists that regulate the functions of BMPs during embryonic development and tissue differentiation. BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. The PRDC gene is mapped to chromosome 1q43.
Product Categories/Family for GREM2 elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19320 MW
NCBI Official Full Name
gremlin-2
NCBI Official Synonym Full Names
gremlin 2, DAN family BMP antagonist
NCBI Official Symbol
GREM2
NCBI Official Synonym Symbols
PRDC; DAND3; STHAG9; CKTSF1B2
NCBI Protein Information
gremlin-2
UniProt Protein Name
Gremlin-2
Protein Family
UniProt Gene Name
GREM2
UniProt Synonym Gene Names
CKTSF1B2; DAND3; PRDC
NCBI Description
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
