Glucagon Like Peptide 2 (GLP2) Recombinant Protein | GLP2 recombinant protein

Recombinant Glucagon Like Peptide 2 (GLP2)

Cat. Num. AAA2105436

• Gene Names: Gcg; Glu; PPG; GLP-1
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Glucagon Like Peptide 2 (GLP2); Recombinant Glucagon Like Peptide 2 (GLP2); GLP2 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic Expression
• Purity/Purification: > 90%
• Form/Format: Freeze-Dried Powder; PBS, pH7.4, Containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: His146~Asp178
• Sequence Length: 180

• Applicable Applications for GLP2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Species: Mouse
• Tag: N-terminal His and GST-Tag
• Isoelectric Point: 4
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Subcellular Location: Secreted
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 33468853
• NCBI GeneID: 14526
• NCBI Accession #: NP_032126.1
• NCBI GenBank Nucleotide #: NM_008100.4
• UniProt Accession #: P55095
• Molecular Weight: Predicted MW: 33.8kDa; Accurate MW: 37kDa
• NCBI Official Full Name: glucagon preproprotein
• NCBI Official Synonym Full Names: glucagon
• NCBI Official Symbol: Gcg
• NCBI Official Synonym Symbols: Glu; PPG; GLP-1
• NCBI Protein Information: glucagon
• UniProt Protein Name: Glucagon
• Protein Family: Germin-like protein
• UniProt Gene Name: Gcg
• UniProt Synonym Gene Names: GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2

NCBI Description

This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]

Uniprot Description

GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2 C1.3|2 35.85 cM

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: glucagon receptor binding; hormone activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of apoptosis; negative regulation of appetite; positive regulation of cAMP biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein kinase activity; regulation of insulin secretion; response to starvation