SDS-PAGE
FLRT2 recombinant protein
Recombinant Mouse FLRT2 Protein (His tag)
Purity
> 95 % as determined by SDS-PAGE
Synonyms
FLRT2; Recombinant Mouse FLRT2 Protein (His tag); FLRT2 recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
660
Application Notes
The recombinant mouse FLRT2 comprises 515 amino acids and has a predicted molecular mass of 57.6 kDa. The apparent molecular mass of the protein is approximately 68-78 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Cys 36
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for FLRT2 recombinant protein
Background: Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct, highly regulated expression pattern, as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development, and it was also present in the vomero-nasal organ, mandibular primodia, and the posterior aspects of the unfused and fused secondary palatal shelves.
Description: A DNA sequence encoding the mouse FLRT2 (Q8BLU0) (Met1-Ser539) was expressed with a C-terminal polyhistidine tag.
Description: A DNA sequence encoding the mouse FLRT2 (Q8BLU0) (Met1-Ser539) was expressed with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
73,948 Da
NCBI Official Full Name
leucine-rich repeat transmembrane protein FLRT2
NCBI Official Synonym Full Names
fibronectin leucine rich transmembrane protein 2
NCBI Official Symbol
Flrt2
NCBI Protein Information
leucine-rich repeat transmembrane protein FLRT2
UniProt Protein Name
Leucine-rich repeat transmembrane protein FLRT2
Protein Family
UniProt Gene Name
Flrt2
Uniprot Description
FLRT2: May have a function in cell adhesion and/or receptor signaling.
Protein type: Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12|12 E
Cellular Component: cytoplasm; extracellular space; focal adhesion; integral to plasma membrane; intercellular junction
Molecular Function: chemorepellent activity; fibroblast growth factor receptor binding; protein binding; protein kinase inhibitor activity
Biological Process: axon guidance; cytokine and chemokine mediated signaling pathway; fibroblast growth factor receptor signaling pathway; heart morphogenesis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; positive regulation of synaptogenesis
Research Articles on FLRT2
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Product Notes
The FLRT2 flrt2 (Catalog #AAA2546675) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse FLRT2 comprises 515 amino acids and has a predicted molecular mass of 57.6 kDa. The apparent molecular mass of the protein is approximately 68-78 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the FLRT2 flrt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FLRT2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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