FGF4 recombinant protein

FGF4

Cat. Num. AAA517000

• Gene Names: FGF4; HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• Applications: Cell Assay
• Synonyms: FGF4; Heparin-binding growth factor 4; HBGF-4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Transforming protein KS3; FGFK; KFGF; Kaposi's sarcoma associated FGF; FGF4 recombinant protein

• Host: E Coli
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS (pH8.0)

• Applicable Applications for FGF4 recombinant protein: Cell Assay
• Species: Human
• Endotoxin Level: <1.0EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1mg/ml. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Activity

(Sample Cell Assay Data: The ED50 as determined by the dose-dependent stimulation of mouse fibroblasts was )

SDS-Page

(Purity: Recombinant Human FGF4 resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250.)

Related Product Information for FGF4 recombinant protein

Recombinant Human FGF4 was expressed in E Coli cells. The protein accession number is P08620
A member of the FGF family, FGF4 plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. FGF4 binds to anionic glycosaminoglycans heparin and heparin sulfate with high affinity and mediates its diverse functions through the FGF receptors (FGFR) 1c, 2c, 3c, and 4. Human FGF4 is known to exhibit cross species activity with mouse, rat, bovine and canine FGF4. Recombinant Human FGF4 is a single polypeptide of 20kDa.

Product Categories/Family for FGF4 recombinant protein

Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4503701
• NCBI GeneID: 2249
• NCBI Accession #: NP_001998.1
• NCBI GenBank Nucleotide #: NM_002007.2
• UniProt Accession #: P08620; B7U994; AAB21430
• Molecular Weight: 12,237 Da
• NCBI Official Full Name: fibroblast growth factor 4
• NCBI Official Synonym Full Names: fibroblast growth factor 4
• NCBI Official Symbol: FGF4
• NCBI Official Synonym Symbols: HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4
• NCBI Protein Information: fibroblast growth factor 4; FGF-4; HSTF-1; fibroblast growth factor 4 splice isoform; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; heparin-binding growth factor 4; human stomach cancer, transforming factor from FGF-r
• UniProt Protein Name: Fibroblast growth factor 4
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF4
• UniProt Synonym Gene Names: HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4
• UniProt Entry Name: FGF4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.