Receptor tyrosine-protein kinase erbB-3 (Erbb3) Recombinant Protein | Erbb3 recombinant protein

Recombinant Mouse Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

Cat. Num. AAA1407773

• Gene Names: Erbb3; Her3; C76256; Erbb-3; Erbb3r
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor tyrosine-protein kinase erbB-3 (Erbb3); Recombinant Mouse Receptor tyrosine-protein kinase erbB-3 (Erbb3); partial; Erbb3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 20-641
• Sequence: S EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRFTQLT EILLGGVYIE KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG GNCPPCHEVC KGRCWGPGPE DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPAEE RLDIKYNRPL GECVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP REFVHEAHCF SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP H
• Sequence Length: 622

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Erbb3 recombinant protein

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and
or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

NCBI and Uniprot Product Information

• NCBI GI #: 61098019
• NCBI GeneID: 13867
• NCBI Accession #: NP_034283.1
• NCBI GenBank Nucleotide #: NM_010153.1
• UniProt Accession #: Q61526; Q3KQR1; Q68J64; Q810U8; Q8K317
• Molecular Weight: 147,613 Da
• NCBI Official Full Name: receptor tyrosine-protein kinase erbB-3
• NCBI Official Synonym Full Names: erb-b2 receptor tyrosine kinase 3
• NCBI Official Symbol: Erbb3
• NCBI Official Synonym Symbols: Her3; C76256; Erbb-3; Erbb3r
• NCBI Protein Information: receptor tyrosine-protein kinase erbB-3
• UniProt Protein Name: Receptor tyrosine-protein kinase erbB-3
• Protein Family: Receptor tyrosine-protein kinase
• UniProt Gene Name: Erbb3

Uniprot Description

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.