Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 Polyclonal Antibody | anti-ErbB3 antibody
Polyclonal Antibody to V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ErbB3)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue))
NCBI and Uniprot Product Information
Uniprot Description
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 10 D3|10 77.1 cM
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral component of membrane; lateral plasma membrane; membrane; nucleus; postsynaptic membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; kinase activity; neuregulin binding; neuregulin receptor activity; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein tyrosine kinase activator activity; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: cranial nerve development; endocardial cushion development; epidermal growth factor receptor signaling pathway; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphorylation; positive regulation of cardiac muscle tissue development; positive regulation of gene expression; positive regulation of glucose import; protein amino acid phosphorylation; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ErbB3
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Product Notes
The ErbB3 erbb3 (Catalog #AAA2026878) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ErbB3) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the ErbB3 erbb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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