EGFL6 recombinant protein

EGFL6 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8123199

• Purity: >95% as determined by SDS-PAGE
• Synonyms: EGFL6; EGFL6 Protein; Mouse; Recombinant (His Tag); Mouse EGFL6/EGF-L6 Protein (His Tag); Egfl6 Protein; Maeg Protein; MGC141463 Protein; EGF-like-domain; multiple 6; EGFL6 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Thr287-Gly550

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Thr 287
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse Egfl6 (NP_062270.1)(Thr287-Gly550) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for EGFL6 recombinant protein

Background: EGFL6, also known as EGF-L6, belongs to the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. EGFL6 contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. EGFL6 gene is expressed early during development, and its expression has been detected in lung and meningioma tumors.

References

Kimura K. et al., 2006, Genome Res. 16 (1): 55-65. Lee SH. et al., 2008, Pathology. 40 (1): 95-7. Oberauer R. et al., 2010, Mol Cell Biochem. 343 (1-2): 257-69.

NCBI and Uniprot Product Information

• NCBI GI #: 9506563
• NCBI Accession #: NP_062270.1
• NCBI GenBank Nucleotide #: NP_062270.1
• UniProt Accession #: Q9JJZ5
• NCBI Official Full Name: epidermal growth factor-like protein 6
• UniProt Protein Name: Epidermal growth factor-like protein 6
• Protein Family: Epidermal growth factor-like protein
• UniProt Gene Name: Egfl6
• UniProt Synonym Gene Names: Maeg; EGF-like protein 6
• UniProt Entry Name: EGFL6_MOUSE

Uniprot Description

EGFL6: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Belongs to the nephronectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: proteinaceous extracellular matrix; membrane; extracellular region; basement membrane

Molecular Function: calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; multicellular organismal development; cell adhesion; cell differentiation