Rat Pro-epidermal growth factor ELISA Kit | Egf elisa kit

Rat Pro-epidermal growth factor ELISA Kit

Cat. Num. AAA2882784

• Reactivity: Rat
• Synonyms: Pro-epidermal growth factor; Rat Pro-epidermal growth factor ELISA Kit; EGF; Egf; Egf elisa kit

• Reactivity: Rat
• Sequence Length: 1133

• Assay Type: Sandwich
• Detection Range: 15.6-1000 pg/ml
• Sensitivity: 7.8 pg/mL
• Intra-Assay CV: <=5.2%
• Inter-Assay CV: <=10.5%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6978797
• NCBI GeneID: 25313
• NCBI Accession #: NP_036974.1
• NCBI GenBank Nucleotide #: NM_012842.1
• UniProt Accession #: P07522; Q63183
• Molecular Weight: 124,126 Da
• NCBI Official Full Name: pro-epidermal growth factor
• NCBI Official Synonym Full Names: epidermal growth factor
• NCBI Official Symbol: Egf
• NCBI Protein Information: pro-epidermal growth factor
• UniProt Protein Name: Pro-epidermal growth factor
• Protein Family: Pro-epidermal growth factor
• UniProt Gene Name: Egf
• UniProt Synonym Gene Names: EGF
• UniProt Entry Name: EGF_RAT

NCBI Description

binds the epidermal growth factor receptor; may play a role in MAP kinase mediated signaling pathways [RGD, Feb 2006]

Uniprot Description

EGF: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Hormone

Cellular Component: extracellular space; integral to membrane; intracellular; lysosomal membrane; plasma membrane; receptor complex

Molecular Function: calcium ion binding; epidermal growth factor receptor binding; growth factor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: activation of MAPK activity; activation of MAPKK activity; angiogenesis; branching morphogenesis of a tube; epidermal growth factor receptor signaling pathway; kidney development; negative regulation of secretion; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor activity; positive regulation of fibroblast proliferation; positive regulation of granule cell precursor proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; regulation of protein secretion; regulation of protein transport; STAT protein nuclear translocation; Wnt receptor signaling pathway through beta-catenin