Phosphoglycerate Kinase 1 Active Protein | PGK1 active protein

Recombinant Mouse Phosphoglycerate Kinase 1

Cat. Num. AAA140679

• Gene Names: Pgk1; Pgk-1
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Phosphoglycerate Kinase 1; Recombinant Mouse Phosphoglycerate Kinase 1; PGK1 Mouse; Phosphoglycerate Kinase 1 Mouse Recombinant; Phosphoglycerate kinase 1 (EC:2.7.2.3); Pgk1; Pgk-1; PGK1 active protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: PGK1 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSLSNK LTLDKLDVKG KRVVMRVDFN VPMKNNQITN NQRIKAAVPS IKFCLDNGAK SVVLMSHLGR PDGVPMPDKY SLEPVAAELK SLLGKDVLFL KDCVGPEVEN ACANPAAGTV ILLENLRFHV EEEGKGKDAS GNKVKAEPAK IDAFRASLSK LGDVYVNDAF GTAHRAHSSM VGVNLPQKAG GFLMKKELNY FAKALESPER PFLAILGGAK VADKIQLINN MLDKVNEMII GGGMAFTFLK VLNNMEIGTS LYDEEGAKIV KDLMSKAEKN GVKITLPVDF VTADKFDENA KTGQATVASG IPAGWMGLDC GTESSKKYAE AVGRAKQIVW NGPVGVFEWE AFARGTKSLM DEVVKATSRG CITIIGGGDT ATCCAKWNTE DKVSHVSTGG GASLELLEGK VLPGVDALSN V.
• Sequence Length: 417

• Biological Activity: Specific activity: > 500 units/mg. One unit will convert 1 umole of 1,3-Bisphosphoglycerate to 3-PGA per minute at pH 8.0 at 37 degree C.
• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.

Related Product Information for PGK1 active protein

Introduction: PGK1 is an X-linked enzyme that has a major role in the glycolytic pathway. PGK1 is a glycolytic enzyme which catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating an ATP molecule. PGK1 may also act as a cofactor for polymerase alpha. Defects in the PGK1 gene are usually associated with chronic hemolytic anemia, though it can be accompanied by either mental retardation or muscular disease (rhabdomyolysis). Overexpression of PGK1 and its signalling targets are possibly an expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination. It was shown that PGK1 is differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Description: PGK1 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 441 amino acids (1-417 a.a) and having a molecular mass of 47.1kDa.PGK1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for PGK1 active protein

Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 70778976
• NCBI GeneID: 18655
• NCBI Accession #: NP_032854.2
• NCBI GenBank Nucleotide #: NM_008828.3
• UniProt Accession #: P09411; Q3TPE6; Q3UKV8; Q5XJE7
• Molecular Weight: 44,550 Da
• NCBI Official Full Name: phosphoglycerate kinase 1
• NCBI Official Synonym Full Names: phosphoglycerate kinase 1
• NCBI Official Symbol: Pgk1
• NCBI Official Synonym Symbols: Pgk-1
• NCBI Protein Information: phosphoglycerate kinase 1
• UniProt Protein Name: Phosphoglycerate kinase 1
• Protein Family: Phosphoglycerate kinase
• UniProt Gene Name: Pgk1
• UniProt Synonym Gene Names: Pgk-1
• UniProt Entry Name: PGK1_MOUSE

Uniprot Description

PGK1: an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein).

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; Kinase, other

Cellular Component: cytosol; lipid raft; membrane

Molecular Function: ADP binding; ATP binding; phosphoglycerate kinase activity

Biological Process: carbohydrate metabolic process; gluconeogenesis; glycolysis