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Prolactin Active Protein | Prl active protein

Mouse Prolactin

Gene Names
Prl; Prl1a1; AV290867
Reactivity
Mouse
Purity
> 98% by SDS-PAGE
Synonyms
Prolactin; Mouse Prolactin; Recombinant Murine Prolactin; Prl active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Lyophilized
Sequence
MLPICSAGDC QTSLRELFDR VVILSHYIHT LYTDMFIEFD KQYVQD REFM VKVINDCPTS SLATPEDKEQ ALKVPPEVLL NLILSLVQSS S DPLFQLITG VGGIQEAPEY ILSRAKEIEE QNKQLLEGVE KIISQAY PEA KGNGIYFVWS QLPSLQGVDE ESKILSLRNT IRCLRRDSHK VD NFLKVLRC QIAHQNNC
Sequence Length
226
Endotoxin Level
< 0.1 ng per ug of Prolactin
Biological Activity
Determined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.
Related Product Information for Prl active protein
Prolactin (PRL) is a neuroendocrine pituitary hormone. Prolactin is synthesized by the anterior pituitary, placenta, brain, uterus, dermal fibroblasts, decidua, B cells, T cells, NK cells and breast cancer cells. Originally characterized as a lactogenic hormone, further studies have demonstrated broader roles in breast cancer development, regulation of reproductive function, and immunoregulation. In the immune system, Prolactin has been shown to be secreted by human PBMC and to act as a proliferative growth factor. Additionally, Prolactin treatment of human PBMC has been shown to enhance IFNgamma production. In the breast, Prolactin-induced morphogenesis of the mammary cells is mediated through IGF2, which in turn up-regulates cyclin D1. Prolactin has several molecular forms. The predominant form is a monomer; the non-glycosylated form is 23 kDa and the glycosylated form is 25 kDa. Glycosylated Prolactin is removed from the circulation faster and has been reported to have lower biological potency. Mouse Prolactin cDNA encodes a 228 amino acid (aa) residue protein with a putative 31 aa residue signal peptide. The Prolactin receptor is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. B cells, T cells, macrophages, NK cells, monocytes, CD34+ progenitor cells, neutrophils, mammary gland, liver, kidney, adrenals, ovaries, testis, prostrate, seminal vesicles, and hypothalamus have all been shown to express the Prolactin receptor. Three forms of the receptor, generated by differential splicing, have been identified. These isoforms differ in the length of their cytoplasmic domains. It is believed that the short cytoplasmic form is non functional. Prolactin signal transduction involves the JAK/STAT families and Src kinase family.
Product Categories/Family for Prl active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
22.5 kDa
NCBI Official Full Name
Prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
Prl
NCBI Official Synonym Symbols
Prl1a1; AV290867
NCBI Protein Information
prolactin
UniProt Protein Name
Prolactin
Protein Family
UniProt Gene Name
Prl
UniProt Synonym Gene Names
PRL
UniProt Entry Name
PRL_MOUSE

Uniprot Description

Function: Prolactin acts primarily on the mammary gland by promoting lactation.

Subcellular location: Secreted.

Sequence similarities: Belongs to the somatotropin/prolactin family.

Research Articles on Prl

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Product Notes

The Prl prl (Catalog #AAA691943) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Prolactin reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MLPICSAGDC QTSLRELFDR VVILSHYIHT LYTDMFIEFD KQYVQD REFM VKVINDCPTS SLATPEDKEQ ALKVPPEVLL NLILSLVQSS S DPLFQLITG VGGIQEAPEY ILSRAKEIEE QNKQLLEGVE KIISQAY PEA KGNGIYFVWS QLPSLQGVDE ESKILSLRNT IRCLRRDSHK VD NFLKVLRC QIAHQNNC. It is sometimes possible for the material contained within the vial of "Prolactin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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