Oncostatin-M Active Protein | mOSM active protein

Recombinant Mouse Oncostatin-M

Cat. Num. AAA145205

• Gene Names: Osm; OncoM
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Synonyms: Oncostatin-M; Recombinant Mouse Oncostatin-M; OSM Mouse; Oncostatin-M Mouse Recombinant; OSM; OncoM; mOSM active protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Form/Format: OSM protein was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: NRGCSNSSSQ LLSQLQNQAN LTGNTESLLE PYIRLQNLNT PDLRAACTQH SVAFPSEDTL RQLSKPHFLS TVYTTLDRVL YQLDALRQKF LKTPAFPKLD SARHNILGIR NNVFCMARLL NHSLEIPEPT QTDSGASRST TTPDVFNTKI GSCGFLWGYH RFMGSVGRVF REWDDGSTRS R
• Sequence Length: 263

• Solubility: It is recommended to reconstitute the lyophilized Oncostatin M in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of NIH-3T3 mouse embryonic fibroblast cells is < 1 ng/ml, corresponding to a specific activity of > 1.0x106 units/mg.
• Preparation and Storage: Lyophilized Oncostatin M although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Oncostatin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for mOSM active protein

Description: OSM Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.4kDa.The OSM is purified by proprietary chromatographic techniques.

Introduction: Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.

Product Categories/Family for mOSM active protein

Cytokines and Growth Factors; Growth Factors; Oncostatin-M

NCBI and Uniprot Product Information

• NCBI GI #: 61656173
• NCBI GeneID: 18413
• NCBI Accession #: NP_001013383.1
• NCBI GenBank Nucleotide #: NM_001013365.2
• UniProt Accession #: P53347; Q3U1Y5; Q5SPX6
• Molecular Weight: 30,114 Da
• NCBI Official Full Name: oncostatin-M
• NCBI Official Synonym Full Names: oncostatin M
• NCBI Official Symbol: Osm
• NCBI Official Synonym Symbols: OncoM
• NCBI Protein Information: oncostatin-M
• UniProt Protein Name: Oncostatin-M
• Protein Family: Oncostatin
• UniProt Gene Name: Osm
• UniProt Synonym Gene Names: OSM
• UniProt Entry Name: ONCM_MOUSE

Uniprot Description

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter