MCP-5 (CCL12) Active Protein | MCP-5 active protein

Recombinant Mouse MCP-5 (CCL12)

Cat. Num. AAA4159954

• Gene Names: Ccl12; MCP-5; Scya12
• Purity: >95% as determined by SDS-PAGE
• Synonyms: MCP-5 (CCL12); Recombinant Mouse MCP-5 (CCL12); MCP-1-related chemokine; Monocyte chemotactic protein 5; MCP5; Small-inducible cytokine A12; C-C motif chemokine 12; Mcp5; Scya12; Recombinant Mouse Monocyte Chemoattractant Protein-5 (CCL12); MCP-5 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered 20 mM PB solution pH 7.5, 100 mM NaCl.
• Sequence Length: 104

• Bioactivity: Determined by its ability to chemoattract human monocytes using a concentration range of 20-40 ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Related Product Information for MCP-5 active protein

MCP-5 (CCL12) is a chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. It is also a potent active monocyte chemokine that signals through CCR2. It is Involved in allergic inflammation and the host response to pathogens. Also, it may play a pivotal role during early stages of allergic lung inflammation.

NCBI and Uniprot Product Information

• NCBI GI #: 119226206
• NCBI GeneID: 20293
• NCBI Accession #: NP_035461.2
• NCBI GenBank Nucleotide #: NP_035461.2
• UniProt Accession #: Q62401
• Molecular Weight: 10.0 kDa
• NCBI Official Full Name: C-C motif chemokine 12
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 12
• NCBI Official Symbol: Ccl12
• NCBI Official Synonym Symbols: MCP-5; Scya12
• NCBI Protein Information: C-C motif chemokine 12
• UniProt Protein Name: C-C motif chemokine 12
• UniProt Gene Name: Ccl12
• UniProt Synonym Gene Names: Mcp5; Scya12; MCP-5
• UniProt Entry Name: CCL12_MOUSE

Uniprot Description

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region; intracellular

Molecular Function: chemokine activity; CCR2 chemokine receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte migration; MAPKKK cascade; cytoskeleton organization and biogenesis; chemotaxis; macrophage chemotaxis; monocyte chemotaxis; regulation of cell shape; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; immune response; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; astrocyte cell migration