C-C motif chemokine 12 Recombinant Protein | Ccl12 recombinant protein

Recombinant Mouse C-C motif chemokine 12

Cat. Num. AAA1265097

• Gene Names: Ccl12; MCP-5; Scya12
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-C motif chemokine 12; Recombinant Mouse C-C motif chemokine 12; MCP-1-related chemokine; Monocyte chemoattractant protein 5; Monocyte chemotactic protein 5; MCP-5; Small-inducible cytokine A12; Ccl12 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 23-104. Full length of the mature protein.
• Sequence: GPDAVSTPVTCCYNVVKQKIHVRKLKSYRRITSSQCPREAVIFRTILDKEICADPKEKWVKNSINHLDKTSQTFILEPSCLG
• Sequence Length: 104

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Ccl12 recombinant protein

Chotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

References

Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation.Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C., Wershil B.K., Gutierrez-Ramos J.-C.J. Exp. Med. 184:1939-1951(1996) Murine monocyte chemoattractant protein (MCP) -5 a novel CC chemokine that is a structural and functional homologue of human MCP-1.Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F., Luster A.D.J. Exp. Med. 185:99-109(1997) Sequence polymorphisms in the chemokines Scya1 (TCA-3) , Scya2 (monocyte chemoattractant protein (MCP) -1) , and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.J. Immunol. 163:2262-2266(1999)

NCBI and Uniprot Product Information

• NCBI GI #: 119226206
• NCBI GeneID: 20293
• NCBI Accession #: NP_035461.2
• NCBI GenBank Nucleotide #: NM_011331.2
• UniProt Accession #: Q62401; Q9QYD6
• Molecular Weight: 13.3 kDa
• NCBI Official Full Name: C-C motif chemokine 12
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 12
• NCBI Official Symbol: Ccl12
• NCBI Official Synonym Symbols: MCP-5; Scya12
• NCBI Protein Information: C-C motif chemokine 12
• UniProt Protein Name: C-C motif chemokine 12
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl12
• UniProt Synonym Gene Names: Mcp5; Scya12; MCP-5
• UniProt Entry Name: CCL12_MOUSE

Uniprot Description

CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Chemokine

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: angiogenesis; astrocyte cell migration; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of leukocyte migration; protein kinase B signaling cascade; regulation of cell shape